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Triple Negative

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Understanding Triple Negative Breast Cancer

Understanding Triple Negative Breast CancerUnderstanding Triple Negative Breast CancerUnderstanding Triple Negative Breast Cancer

A comprehensive educational tool to help you through your journey.

Become a Member to stay informed

Start here

I'm newly diagnosed

I'm newly diagnosed

I'm newly diagnosed

What TNBC means, how it’s different, and what to do first.

Diagnosis & Staging →

I'm in treatment

I'm newly diagnosed

I'm newly diagnosed

Chemo, surgery, radiation, and side-effect tips you can use this week.

Treatment Options →

I've finished treatment

I'm exploring clinical trials

I'm exploring clinical trials

Follow-up care, monitoring, and getting back to life.

Post-Treatment →

I'm exploring clinical trials

I'm exploring clinical trials

I'm exploring clinical trials

What trials are, safety basics, and how to ask if one’s right for you.

Clinical Trials →

About TNBC

What does "Triple Negative" mean?

  • Triple Negative Breast Cancer or TNBC is a type of breast cancer that doesn’t have estrogen or progesterone receptors, and the HER2 oncogene is negative or not overexpressed.
  • Because those receptors aren’t present, hormone-blocking drugs and HER2-targeted medicines don’t work for TNBC.
  • It can still be successfully treated! Plans often include chemotherapy, surgery, radiation, and, when appropriate, immunotherapy or other targeted options.
  • Your plan is personal. It’s based on your tumor features, stage, health, and preferences.

Learn the basics of TNBC →

Your Treatment Options

There's so much to learn, and we're here to help you understand what path is right for you. Use the summary below to begin understanding some of your options, then dive into our Treatment Options page to learn more. 

Medicines that travel through your bloodstream to kill cancer cells. May be given before surgery (neoadjuvant) or after (adjuvant) depending on your plan. 


  • What it is: Cancer-fighting medicines given by IV or pills.
  • When it’s used: Before surgery to shrink tumors or after surgery to lower risk of return.
  • Ask your team: Goals, schedule, likely side effects, support meds.

Removes the cancer (lumpectomy or mastectomy) and checks lymph nodes (sentinel node biopsy). Your chemo response can shape the surgical plan.


  • What it is: Lumpectomy vs. mastectomy; sentinel node biopsy for staging.
  • When it’s used: After chemo if given first, or up front in some plans.
  • Ask your team: Breast-conserving vs. mastectomy, margins, recovery, reconstruction.

Focused energy to lower the chance of cancer returning in the breast/chest wall or nodes. Common after lumpectomy; sometimes after mastectomy based on risk.


  • What it is: Targeted treatment to reduce recurrence risk.
  • When it’s used: Usually after lumpectomy; considered after mastectomy for higher-risk features.
  • Ask your team: Areas treated, number of sessions, skin care during treatment.

Medicines that help your immune system find cancer cells or deliver chemo directly (antibody-drug conjugates). Eligibility depends on tumor features and stage.


  • What it is: Immunotherapy and antibody-drug conjugates used in specific TNBC situations.
  • Who may benefit: Based on tumor testing and prior treatments.
  • Ask your team: Tests needed (e.g., PD-L1), how it’s given, side-effect monitoring.

Learn more about Treatment Options →

About TripleNegative.com

TripleNegative.com is the trusted, specialized resource for patients and families navigating triple-negative breast cancer (TNBC). We focus on clear explanations, actionable checklists, and questions to ask your care team, reviewed by experts so you can move forward with confidence.


  • Medical reviewer: William Diehl, MD, FACS is a board-certified surgical oncologist and breast surgeon with special expertise in TNBC.
  • How we work: We translate current clinical guidance and peer-reviewed research into plain language, add practical next steps, and show review dates and sources on every page.
  • What we don’t do: We don’t replace your medical team. Use this site to prepare for conversations and decisions together.

Our Mission

Our Mission

Our Mission

Equip people impacted by triple-negative breast cancer with clear, compassionate, and current information so every visit may lead to a practical next step.

Our Vision

Our Mission

Our Mission

A world where a TNBC diagnosis is met with clarity, options, and hope, leaving no one feeling alone, and ensuring the right information reaches the right person at the right time.

Our Promise

Our Mission

Our Promise

We  provide clear, compassionate, evidence-based information—always free to read and easy to use.

Become a member

Membership is free and entitles you to receive updates regarding new treatments, clinical trials, and medical breakthroughs with regard to Triple Negative Breast Cancer (TNBC). You will be notified of new blog posts by our panel of experts and when any major break-throughs are reported. Note: Your personal information will not be sold, transferred or shared with any other site on the web.

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This website is for educational purposes only. All treatment decisions should be made by you through the advice from your doctor.

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